Manchester City, Fulham, Brigthon and a second-tier league team, Blackburn Rovers have all booked their places in the FA quarter-finals following the games played on Tuesday night.
Three Lions midfielder, Phil Foden, scored twice as the Premier League champions thrashed Bristol City 3-0.
Kevin De Bruyne rounded off the scoring with a sublime finish from 25 yards.
Blackburn Rovers became giant killers on the night after beating Leicester City, who were playing at home 2-1.
Tyrhys Dolan and Sammie Szmodics scored for the second-tier team before Nigerian striker, Kelechi Iheanacho reduced the deficit.
Fulham reached the sixth round for the first time in 13 years thanks to goals by Joao Palhinha and Manor Solomon, which earned them a 2-0 win over Leeds United.
Brighton and Hove Albion needed Evan Ferguson’s first-half goal to claim a 1-0 away win over second-tier Stoke City.
In the outstanding FA Cup fifth-round ties which will be played today, Wednesday, March 1, Southampton will host Grimsby, while Burnley will face Fleetwood.
Man United, who recently won the Carling Cup will also welcome London club, West Ham at Old Trafford, while Sheffield United will play Tottenham Hotspurs.